Can Profit Calc have multiple stores in different currencies?

The multiple store setting can work with multiple currencies no problem! The best way to do so is to have one of the stores set as the "default" store. Then the other store will be converted into the currency of the "default" store using the dashboard conversion setting.

For example:

(Store X is in Euros whereas Store Y is in SEK).

For the dashboard calculations to be accurate. Store X would remain in Euros, but Store Y would need to be converted from SEK => Euros.